INSETICIDA ORGANOFOSFORADO METAMIDOFÓS:: aspectos toxicolpógicos e complicações decorrentes da intoxicação

Abstract

The present work aims to carry out a bibliographical review, descriptive and transversal, on the organophosphate Metamidophos. Methamidophos is an insecticide belonging to the class of organophosphate compounds and according to the toxicological classification of Anvisa, it belongs to class I (extremely toxic). It is used against a wide variety of insects, and is allowed to be used for some crops in Brazil, such as: cotton, peanuts, potatoes, beans, soybeans, tomatoes and wheat. As it is highly toxic, when in contact with humans and animals, it can be absorbed through the dermal, respiratory and oral routes, being rapidly distributed throughout the body, where it undergoes hydrolysis and demethylation, and is mainly excreted in the urine. Its toxicity is mainly determined by the enzymatic inhibition of acetylcholinesterase (AChE). This exposure generates several problems for the human body, such as acute and chronic poisoning, syndromes (intermediate, delayed polyneuropathy, Parkinson's disease and cancer), in addition to interfering with development and reproduction. In workers and people exposed to methamidophos, a periodic monitoring thus avoiding future health problems The treatment of poisoning by the compound in question is mainly based on the use of atropine and pralidoxime. These two drugs work in synergism. Although pesticides are extremely necessary products in the culture of various products, they present many risks to the health of exposed people, requiring a more effective prevention policy, with greater attention focused on the correct use of PPE (Personal Protection Equipment) and EPC's (Equipment Protection), training and information programs in order to guarantee ever lower and safer exposure levels.