AVALIAÇÃO DAS DOSAGENS DE IMUNOGLOBULINAS E PROTEÍNAS DO COMPLEMENTO EM INDIVÍDUOS EXPOSTOS À SÍLICA

Abstract

Silicosis is one of the most prevalent and important pneumoconiosis, being an irreversible disease without specific treatment. The disease is related to certain types of occupation in which there is a high concentration of crystalline silica or silicon dioxide in the work environment. The form of diagnosis of the disease is made through radiological reports, being marked by the presence of silicotic nodules in the pulmonary tract. This disease can appear either after 20 years of exposure to silica, or after months of massive exposure. causing countless inconveniences to individuals, mainly the loss of lung elasticity, resulting in the inability to work. The aim of this work was to evaluate the profile of IgA-type immunoglobulins. IgG and leM. as well as C3 and C4 complement proteins by the immunoturbidimetry method, in mining workers located in the city of São Thomé das Letras, a city whose main activity is the export of quartz. Based on the results, it was possible to verify the elevation of immunoglobulins in some of the workers, as well as a small variation rate in the dosages in mg/dl. complement system proteins, and it is possible to characterize clinical findings that prove the association of exposure to silica with increased gamma globulins, which suggests the link between silicosis and autoimmune diseases.