REVISÃO BIBLIOGRÁFICA SOBRE O ESTUDO DA CORRELAÇÃO DOS NÍVEIS SÉRICOS DE HOMOCISTEÍNA NA DOENÇA DE ALZHEIMER

Abstract

Alzheimer's disease is a progressive and irreversible neurodegenerative disorder, with a higher incidence in the elderly, associated with lifestyle and genetic factors. One of these factors, homocysteine is known to increase the risk of the disease. An amino acid forming from the metabolism of methionine, which in high doses presents toxicity to the cells of the nervous system. Considered a risk factor for neurodegenerative diseases, studies suggest that homocysteine plays a role in brain damage, cognitive and memory decline. High doses of homocysteine are found in patients with Alzheimer's disease. Numerous studies in recent years have investigated the role of homocysteine as a cause of brain damage. Although incomplete, this review attempts to draw attention to the importance of collaborative studies between clinicians and researchers for potential targets in the development of new research and thus contribute to a better understanding of homocysteine and its importance in the diagnosis of Alzheimer's disease, and possible treatments more effective.