LESÕES RENAIS EM FELINOS E O USO DO BIOMARCADOR DIMETILARGININA SIMÉTRICA NO DIAGNÓSTICO PRECOCE DA DOENÇA RENAL CRÔNICA

Abstract

Chronic kidney disease is a very common illness in small animal clinics, being the second leading cause of death in felines. It is a pathology characterized by functional and/or anatomical disorders of the kidneys. The general objective of this work was to develop a literature review about Chronic Kidney Disease (CKD) in felines, highlighting: the etiology, diagnosis, staging of CKD, tests and the use of Symmetrical Dimethylarginine (SDMA) as a biomarker. CKD was defined as loss related to kidney function, due to structural damage considered as non-reversible, which destroys kidney nephrons. It was identified that the early diagnosis of CKD is possible through complementary tests, and the SDMA marker is the most indicated for the early diagnosis of the pathology in felines, as it has shown greater sensitivity than creatinine. 2015 represented a milestone for the topic, with the implementation of new CKD guidelines by the International Society of Renal Interest - a new classification system, dividing the disease into four stages and, consequently, proposing a more targeted treatment to each one. It was concluded that the use of current available resources only contributes to the quality of life and survival of the animal, allowing the disease not to progress, with SDMA being an additional resource for the diagnosis and monitoring of felines affected by CKD.