INFLUÊNCIA DA INFUSÃO DE "ECLIPTA PROSTRATA" NO TECIDO HEPÁTICO

Abstract

Eclipta prostrata is popularly used in the treatment of liver diseases, however the real mechanisms of the plant on the liver profile is little known. The present study aimed to evaluate the influence of E. prostrata infusion on liver tissue and on the biochemical profile. For this, male Winstar rats were used, which were divided into four groups, with six rats in each group, placebo, negative control, positive control test. The histological and enzymatic results obtained in this model revealed the presence of liver dysfunction in the negative control group and a blockage of the process in the test group. With these data, it is suggested that the plant has two functions, of hepatoprotection and hepatotoxicity, depending on the hepatic stimulation exerted. In order to define which substances are responsible for these opposite responses, further studies are needed to evaluate the substances acting on the liver profile. The results obtained, added to additional studies, may contribute to the manufacture of a new herbal medicine and thus help in the treatment and prevention of liver diseases.